Puma Biotechnology pipeline

GAlthough we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes - just in case they're material to our investing thesis.

What: Shares in Puma Biotechnology collapsed by more than 15% earlier today after abstracts to be presented at the upcoming American Society of Clinical Oncology meeting were released.

So What: The abstracts include data on Puma Biotechnology's neratinib, or PB272, a cancer-fighting drug that is the company's lead product candidate.

Specifically, abstract #508 includes a summary of neratinib's phase 3 trials in early stage HER2+ breast cancer patients. In the placebo-controlled study, patients that had been previously treated with Roche Holdings' top-selling Herceptin were given neratinib in a bid to boost the number of people who are disease-free at the two-year mark.

The abstact shows that 93.9% of patients in this trial were disease-free after two years, which was only slightly better than the 91.6% rate for those receiving the placebo.

Now What: The small advantage in the neratinib arm of this study appears to be less than what industry watchers were hoping for, but investors should remember that breast cancer is the second leading cause of cancer death among women and that the need for new treatment options that extend patient lives longer is significant. Further, while the advantage is tepid, the study will continue to evaluate patients for five years, and the five-year findings could improve upon, confirm, or fall short of the two-year results.

Additionally, investors also need to remember that neratinib is being evaluated in additional studies, including a phase 2 trial evaluating it as a first-line treatment in HER2+metastatic breast cancer, as well as in HER2 mutated metastatic non-small cell lung cancer.

Interesting facts
10 Trichocereus Pachanoi 'Mystery' Seeds (San Pedro Cactus)
Lawn & Patio
  • In addition to our other San Pedro seeds, we have these, which we are calling the San Pedro Mystery . We got these from one of our suppliers as a new form of Trichocereus...
  • Trichocereus Pachanoi is perhaps the most famous of the trichocereus species. This easy-to-grow, ornamental, columnar cactus is popular for a variety of reasons...
  • Growing Information: Seeds should be germinated in a fine sandy soil at about 70-75 degrees. A commercial potting mix with the larger material strained out is ideal...
Paulownia Tree Paulownia Catalpifolia 50 Seeds
Lawn & Patio
  • Fastest Growing Shade Tree! Some biologist argue it is not really another species, but rather a cross between tomentosa and elongata. The flowerâ€TMs color is not...
  • Trees will not do well in overly wet soils or salt sea air. Paulownia trees may be grown in colder climates, but the tree will die back to the ground every winter...
  • Paulownia is a genus of between 6-17 species of plants in the monogeneric family Paulowniaceae, related to and sometimes included in the Scrophulariaceae. They are...
  • For centuries, the Chinese have grown Paulownia, also known as Empress and Sapphire trees for beauty and for highly-prized timber. Paulownia is a fast-growing shade...
Astrophytum Hybrids Cactus Succulent Seeds - Sand Dollar Cactus, Sea Urchin Cactus - HIGHLY DESIRABLE & SOUGHT AFTER - Gorgeous Patterns and Markings - FRESH SEEDS - By MySeeds.Co (0100 Seeds - 100 Seeds)
Lawn & Patio (MySeeds.Co)
  • Astrophytum Hybrids, Seeds
  • How to Grow a Star Cactus Mist the soil when caring for star cactus babies as overhead watering can damage the tender tissues. They will need to be kept moist until...
  • Astrophytum Cactus Care Novice gardeners love the ease of cacti care as interior plants. They thrive on neglect, although star cactus plants will need water occasionally...
  • (Sand Dollar Cactus, Sea Urchin Cactus) The root of the name astrophytum refers to the stars, as in the word astronomy, which reflects a somewhat star-shaped...
Watermelon Seeds,'congo'- Non-gmo Heirloom 50 Seeds, Large Fruit, 30 to 50 Lbs !
Lawn & Patio
  • Saving Congo Watermelon Seeds: Watermelons will cross with other varieties of watermelon, so isolation may be necessary to ensure genetic purity. When the melon...
  • Watermelon Seeds - CongoThis watermelon variety has one of the highest sugar contents of any watermelon! Congo produces large cylindrical fruit with blunt ends...
  • About Congo Watermelon: As the name of this melon suggests, watermelons originated in Africa, specifically Egypt. In these desert regions, wild watermelons provided...
  • Gardeners in warm climates will be able to direct sow watermelons as soon as the soil temperature reaches at least 75 degrees F, planting six seeds per hill with...
  • Harvesting Congo Watermelon: Gardeners use many different methods of testing whether their watermelons are ripe, but knowing the approximate mature size of the melon...
Beet Seeds - White Beets (Albino Beets) "Heirloom, From Holland ! Very Rare !
Lawn & Patio
  • For best taste and tenderness, do not allow beets to grow over 3 in diameter. After pulling them, twist off the tops about 1 up the stem. Up to one third of the...
  • Beet plants must weather the winter in order to produce seed; in warmer climates, simply mulch the plants. In cooler climates, dig up the roots and store them in...
  • white beets (albino beets) White Albino Beet Info: Beta vulgaris. Biennial. 50 days to maturity. 1500 seeds an oz. 6-12 in height. 9-4 spacing. Produces 3-4...
  • American colonists later brought them to the New World, where they became a commonly enjoyed food both for their roots and their greens. According to historians...
  • Growing White Albino Beet Seeds: Since each beet seed holds up to eight actual seeds, the seedlings will need to be thinned to 4 apart. The thinned plants do...
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